What's the Buzz About Hydroxyapatite?

 

What's the Buzz About Hydroxyapatite?
Dr Rita Trak, 17th June, 2026

As a holistic dentist, I am always looking for ingredients that are biocompatible, meaning they work in harmony with the body's natural tissues and processes without causing unnecessary irritation or toxicity while still delivering real results. This is important because the products we use in our mouths every day have the potential to impact not only our oral health but our overall wellbeing. 

One ingredient I have been especially excited about in recent years is Hydroxyapatite. 

Hydroxyapatite helps replenish and support enamel by providing the same mineral building blocks that our teeth are naturally made from. As the primary mineral found in our teeth and bones, it offers a biomimetic approach to oral care by working with the body's natural repair processes rather than relying on ingredients introduced from external sources. 

Although Hydroxyapatite may seem like a relatively new trend in oral care, it has actually been used in toothpaste for over four decades. The technology originated from research conducted in the 1970s exploring ways to help astronauts restore mineral loss in their teeth and bones during space missions. This research eventually led to the development of the world's first Hydroxyapatite toothpaste in Japan, which was launched in 1980. Since then, Hydroxyapatite has been extensively researched and used in oral care products around the world for its ability to support enamel remineralisation and reduce sensitivity. 

I am such a fan of Hydroxyapatite because it combines the best of both worlds. Not only is it naturally found within the body, but research has also shown it to be highly effective at supporting enamel remineralisation, reducing tooth sensitivity and strengthening the tooth surface. What I love most is that it helps restore and protect enamel in a way that feels truly biocompatible. For me, Hydroxyapatite represents a more natural approach to oral care without compromising on effectiveness. 

Everyday eating and drinking can gradually create tiny, microscopic scratches and surface irregularities in our enamel over time. Research suggests that Hydroxyapatite can help fill and repair these microscopic defects, helping to strengthen enamel, improve surface smoothness, reduce sensitivity and support a brighter, healthier looking smile. 

While Hydroxyapatite is an excellent ingredient in toothpaste, it is important to understand that not all forms of Hydroxyapatite are the same. There are two key factors I recommend consumers consider when choosing a Hydroxyapatite toothpaste. 

1. Nano vs Non-Nano Hydroxyapatite 

The first factor is whether the toothpaste contains nano or non-nano Hydroxyapatite. These terms refer to particle size and the distinction is important. 

Non nano Hydroxyapatite, also known as micro-Hydroxyapatite, primarily remains on the tooth surface where it can help support enamel remineralisation and reduce sensitivity. Nano Hydroxyapatite consists of particles smaller than 100 nanometres in size and was developed to more closely mimic the natural structure of enamel crystals. 

While nano Hydroxyapatite has demonstrated promising benefits for enamel remineralisation, its use remains the subject of ongoing scientific debate. Due to their extremely small size, nanoparticles can behave differently from larger particles within biological systems. Some researchers have raised concerns that certain nanoparticles may be capable of penetrating biological barriers, accumulating within tissues and potentially enhancing the penetration of other substances into cells. 

The unique properties that make nanoparticles attractive for medical and dental applications also make their safety difficult to fully evaluate. Their extremely small size can make them challenging to detect, measure and monitor within biological systems, meaning that questions regarding long term accumulation and potential health effects remain the subject of ongoing research. 

As a result, many health-conscious consumers choose non nano Hydroxyapatite toothpaste as a precautionary approach. 

2. The Percentage of Hydroxyapatite Matters 

The second factor to consider is the concentration of Hydroxyapatite in the formula. 

Some toothpastes contain as little as 5% Hydroxyapatite while others contain 10% or more. Manufacturers are not always required to disclose the percentage used, making it difficult for consumers to compare products. 

Research suggests that formulations containing around 10% Hydroxyapatite can effectively adhere to the tooth surface, help reduce sensitivity and support the natural remineralisation process. Importantly, many of the clinical studies demonstrating the benefits of Hydroxyapatite toothpaste have used formulations containing approximately 10% Hydroxyapatite. 

My Personal Recommendation 

Why I Recommend Grants Whitening +HA Toothpaste 

I completely understand that this can feel confusing to navigate, especially when the terminology sounds highly technical. The distinction between nano and non-nano Hydroxyapatite is still an emerging topic within oral care, which means many consumers are unaware of the differences and the questions they should be asking when selecting a toothpaste. 


One toothpaste I personally love and recommend is Grants of Australia Whitening +HA Toothpaste because it aligns closely with the principles I look for in oral care: biocompatibility, transparency and evidence informed ingredients. 

The formula contains 10% non-nano Hydroxyapatite, a concentration commonly used in clinical studies investigating Hydroxyapatite's role in enamel remineralisation and sensitivity reduction. This is particularly important because many brands do not disclose the percentage of Hydroxyapatite used in their products, making it difficult for consumers to compare formulations. 

What I particularly appreciate about this toothpaste is the combination of Hydroxyapatite and calcium carbonate, as each ingredient plays a unique role in supporting oral health. Hydroxyapatite helps replenish and support enamel by providing the same mineral building blocks that our teeth are naturally made from, while calcium carbonate, a naturally derived mineral, helps gently remove plaque and surface stains while polishing the tooth surface without excessive abrasion. Together they create a complementary system where one ingredient helps strengthen and protect while the other helps clean and brighten. 

Another feature that stands out is the source of the Hydroxyapatite itself. It is a non-nano Hydroxyapatite of natural mineral origin and is also vegan. For consumers seeking ingredients that align with a more natural and biocompatible approach to oral care, this may be an important consideration. 

For me, the strength of this toothpaste lies not in any single feature but in the overall formulation. It combines ingredients that support enamel health, gentle cleaning and a more holistic approach to oral care, making it a product I feel confident recommending to patients who are looking for a Hydroxyapatite based alternative. 

For me, Hydroxyapatite represents one of the most exciting advances in modern oral care because it supports stronger, smoother and healthier looking teeth using the very same mineral our teeth are naturally made from. As awareness grows, I believe it is important for all of us to become more informed consumers and ask questions about what is really inside the products we use every day. 

Shop Grants Whitening +HA here

References 

  1. Pepla E, Besharat LK, Palaia G, Tenore G, Migliau G. Nano hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature. Annali di Stomatologia. 2014;5(3):108–114. 

  1. Amaechi BT, AbdulAzees PA, Alshareif DO, et al. Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralisation of dental caries in children. BDJ Open. 2019;5:18. 

  1. Paszynska E, Pawinska M, Gawriolek M, et al. Evaluation of the efficacy of hydroxyapatite toothpaste in reducing dentine hypersensitivity and supporting enamel remineralisation. Journal of Clinical Medicine. 2021;10(11):2463. 

  1. ANSES. Assessment of risks related to nanomaterials. French Agency for Food, Environmental and Occupational Health and Safety. Available at: https://www.anses.fr/fr/system/files/AP2012sa0273Ra.pdf 

  1. VeilleNanos. What are the health risks of nanomaterials? August 2023. Available at: https://veillenanos.fr/dossier/risques/sante/risques-sante/ 

  1. Murugadoss S, Lison D, Godderis L, et al. Toxicology of silica nanoparticles: an update. Archives of Toxicology. 2017;91(9):2967–3010. doi:10.1007/s00204-017-1993-y 

  1. Chan WT, Liu CC, Chiang Chiau JS, et al. In vivo toxicologic study of larger silica nanoparticles in mice. International Journal of Nanomedicine. 2017;12:3421–3432. doi:10.2147/IJN.S126823 

Disclaimer 

This article is intended for educational purposes only and should not be considered personalised dental, medical or healthcare advice. Always consult your dental or healthcare professional regarding your individual needs and treatment options.

About Dr. Rita Trak
(Dr Margarita Trakhtman; Registered Dentist AHPRA Registration No. DEN0001929543) 

Dr. Rita Trak is a holistic dentist, founder of Melbourne’s Dental and Skin Clinic and now, Grants of Australia’s Lead Dentist and Oral Health Advisor.  For more information, please visit her full bio.

Or follow Dr. Rita on Instagram – @dentalandskin